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Hilar cholangiocarcinoma is a type of bile duct cancer that occurs in the bile ducts that lead out of the liver (hepatic ducts) and join with the gallbladder. Hilar cholangiocarcinomas are also known as Klatskin tumors.
The gallbladder serves as a reservoir for bile, a yellow-green fluid produced in your liver. Bile flows from your liver into your gallbladder, where it's held until needed during the digestion of food. When you eat, your gallbladder releases bile into the bile duct, where it's carried to the upper part of the small intestine (duodenum) to help break down fat in food.
Diagnosis
Tests and procedures used to diagnose hilar cholangiocarcinoma include:
Imaging tests, such as a CT and MRI
Blood test for very high levels of CA 19-9 tumor maker
Biopsy using ERCP and specialized lab testing with fluorescence in situ hybridization (FISH)
Doctors typically don't recommend collecting cells using a needle inserted through your skin and into your bile duct (transperitoneal biopsy). This technique increases the risk of cancer recurrence and may make you ineligible for a liver transplant.
Treatment
Which treatment is best for you will depend on the location and extent of your hilar cholangiocarcinoma. Treatment typically involves surgery, liver transplant or supportive treatments to reduce your pain and other symptoms.
Surgery
Surgery for hilar cholangiocarcinoma involves removing the:
Cancer
Surrounding bile ducts
Portions of the liver
Nearby lymph nodes
The surgeon then connects the remaining bile ducts to the small intestine so that bile can still reach your digestive tract and help digest food.
Liver transplant
People with early-stage hilar cholangiocarcinoma who aren't able to undergo surgery may consider liver transplant. Chemotherapy and radiation are typically used before the liver transplant in order to kill as many cancer cells as possible before surgery.
This treatment typically involves:
Intravenous chemotherapy with a medicine that makes your cells more vulnerable to radiation
External beam radiation therapy
Internal radiation (brachytherapy) using small wires that are placed near the cancer and slowly release radiation
Chemotherapy in pill form until transplant surgery
Minimally invasive surgery to look for signs that cancer has spread
Liver transplant with a donor liver if one becomes available
You may undergo routine tests to evaluate your health while waiting for a liver transplant to make sure you're healthy enough for the surgery.
Chemotherapy
People with advanced hilar cholangiocarcinoma who aren't able to undergo surgery or liver transplant may receive chemotherapy to slow the growth of the cancer.
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